Endocrine Abstracts

Mammalian pregnancy is characterized by tremendous changes and adaptations in the endocrine as well as in the immune system. Early in pregnancy, levels of female sex hormones, progesterone (P4) and estradiol (E2) produced by the corpora lutea (CL) significantly rise, promoting huge modifications of the uterine epithelium ensuring embryo implantation. Once the embryo is implanted, trophoblast cells produce and release increasing levels of human chorionic g...

In 2007 a qualitative study of 36 patients’ observations of diseases, care and life disorders associated with Acromegaly was conducted. Inclusion and exclusion criteria are described. The sample cuts across both gender and age. Seven patients didn’t want to participate. The reason for this is only known for some of them. A literature search in a pilot study of nine patients revealed that this patient group was qualitative unexplored. Research interviews were conducte...

Background: Acromegalia is an infrequent chronic disease requiring lifelong control. A total of about 350 Danish patients have acromegalia. It is difficult for this patient group to find information on coping strategies in fellow patients.There are numerous international quantitative studies on the symptoms in acromegalia patients; no qualitative studies on self-observations as a way to exchange experiences and optimize nursing in connection with hospita...

Objective: Altered appearance and changed visual function characterize thyroid associated orbitopathy (TAO). TAO affects face and eyes and influences social function. It is well documented that thyroid disease influences the patient’s quality of life negatively and TAO aggravates the situation. Recently, attention has been directed towards the impact of the patient’s body image and studies show how body image dissatisfaction is a significant psychosocial complication...

In 2014–2015, a study of patients’ quality of life after training in self-management of monthly Ipstyl injections is implemented. These injections were previously given by their GPs. Inclusion criteria are described. Sample cuts across gender and age. Ten patients did not respond to mailed offers and 12 did not participate. The reason for this is only known to some of them. Six patients wanting training are invited to an introduction of self-management of Ipstyl and ...

The neuropeptide oxytocin is the most recent peptide to have emerged from a new field of research investigating the physiological underpinnings of human social behaviour. Whilst previous studies have focused on the role of touch as an effective method of priming, this study investigated the role of social vocalisation as a potential priming method of endogenous oxytocin release. 40 female participants, aged between 18 and 21 years of age, were randomly allocated into either a ...

Background: Maternal circulating cortisol and 24-h urinary free cortisol levels are up to three times higher in third trimester pregnant women compared to non-pregnant women. Maternal cortisol status could be associated with offspring sex, maternal PCOS and testosterone levels.Aims: To determine predictors of maternal serum (S) and urinary (U) cortisol and cortisone levels during 3rd trimester and to examine associations between maternal cortisol status,...

Introduction: A common genetic polymorphism in the GH receptor (GHR) is deletion of the entire exon 3 sequence (GHRd3 isoform). The GHRd3 isoform seems to be more sensitive with increased downstream GH signalling in activated exon 3 deleted receptor dimers (GHRd3/d3) compared to full length receptor dimers (GHRfl/fl). Presence of the GHRd3 isoform might be associated to pre- and postnatal growth and pubertal development in boys, although controversy exists. The aim was to inve...

Background: GH receptors are present in ovaries and GH may have a physiological role for ovarian function and development.Objective and hypothesis: The objective of this study was to examine pubertal development and ovarian growth and differentiation during GH therapy.Methods: Clinical characteristics, reproductive hormones and ultrasonographic examination of the internal genitals were determined in 18 prepubertal girls during 3 ye...

Background: Synthetic glucocorticoid exposure in late pregnancy may be associated with higher blood pressure in offspring. We hypothesized that endogenous cortisol in pregnancy relates to offspring blood pressure (OBP).Objective: To investigate associations between maternal cortisol status in 3rd trimester pregnancy and OBP.Methods: We included 1,317 mother-child pairs from Odense Child Cohort (OCC), an observational prospective co...